国际站：Atorvastatin
CAS：134523-00-5
纯度：96.24%
分子量：558.64
Formula：C33H35FN2O5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
产品活性：Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。Atorvastatin 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。
生物活性：阿托伐他汀是一种口服活性HMG-CoA还原酶抑制剂，具有有效降低血脂的能力。阿托伐他汀抑制人SV-SMC增殖和侵袭的ic50分别为0.39 μM和2.39 μM[1][2][3]。
体外：阿托伐他汀治疗通过下调心肌梗死后心肌细胞GRP78、caspase-12和CHOP的表达，减少心肌细胞凋亡，内质网(ER)应激在心衰和血管紧张素II (Ang II)刺激下被激活[4]。
体内：阿托伐他汀(20-30 mg/kg;口服填喂法;一天一次;28天;ApoE-/-小鼠)处理显著降低了Ang ii诱导的ApoE-/-小鼠内质网(ER)应激信号蛋白、凋亡细胞数量以及Caspase12和Bax的激活。促炎细胞因子如IL-6、IL-8、IL-1β在阿托伐他汀治疗后均明显受到抑制[5]。
参考文献：
[1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.
[2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
[3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [Content Brief]
[4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.
[5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.
[6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.