分子量：Calculated MW: 106kDa/119kDa/121kDa/122kDa/124kDa/126kDa
Observed MW: 125KDa

细胞定位：Cell membrane, Lipid-anchor, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:2000
IF 1:50 - 1:200

总结：The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.